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Drug Guide
 
 

Ponatinib

 
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  •  
    Oral
    Ponatinib
    Iclusig 
     
    Used only if resistance to all other agents, or if T315I mutation
    • Mechanism of Action
    • Inhibit the Bcr-Abl tyrosine kinase as well as the stem cell receptor factor (cKIT) and several other receptor tyrosine kinases.

Clinical Use

    • Indication
    • Chronic myeloid leukaemia with resistance or intolerance to at least two other tyrosine kinase inhibitors, other with T315I mutation
    • Adverse Effects
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