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Ponatinib

  •  
    Oral
    Ponatinib
    Iclusig 
     
    Used only if resistance to all other agents, or if T315I mutation
    • Mechanism of Action
    • Inhibit the Bcr-Abl tyrosine kinase as well as the stem cell receptor factor (cKIT) and several other receptor tyrosine kinases.

Clinical Use

    • Indication
    • Chronic myeloid leukaemia with resistance or intolerance to at least two other tyrosine kinase inhibitors, other with T315I mutation
    • Adverse Effects
    • Rash
    • Fatigue
    • Oedema
    • Nausea / vomiting / diarrhoea
    • Muscle cramping
    • Peripheral neuropathy
    • LFT derangement
    • Myelosuppression - anaemia, neutropaenia, thrombocytopaenia
    • Cardiovascular - cardiac ischaemia, stroke, peripheral vascular disease, hypercholesterolaemia

Potential Indications
BETA

Chronic Myeloid Leukaemia

Associated Adverse Effects
BETA

Peripheral Vascular Disease
Peripheral Vascular Disease
Secondary Hyperlipidaemia
Secondary Hyperlipidaemia
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