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Drug Guide
 
 

Ponatinib

 
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  •  
    Oral
    Ponatinib
    Iclusig 
     
    Used only if resistance to all other agents, or if T315I mutation

  • Mechanism of Action

  • Inhibit the Bcr-Abl tyrosine kinase as well as the stem cell receptor factor (cKIT) and several other receptor tyrosine kinases.

Clinical Use

  • Indications

  • Chronic myeloid leukaemia with resistance or intolerance to at least two other tyrosine kinase inhibitors, other with T315I mutation
  • Adverse Effects
  • Rash
  • Fatigue
  • Oedema
  • Nausea / vomiting / diarrhoea
  • Muscle cramping
  • Peripheral neuropathy
  • LFT derangement
  • Myelosuppression - anaemia, neutropaenia, thrombocytopaenia
  • Cardiovascular - cardiac ischaemia, stroke, peripheral vascular disease, hypercholesterolaemia
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