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Piperacillin-Tazobactam

  •  
    IV
    Piperacillin-Tazobactam
    PipTaz, Tazosin 
     
    Used for severe infections only
    • Mechanism of Action
    • Piperacillin is a beta lactam antibiotic that inhibits bacterial cell wall synthesis. Tazobactam is a a beta lactamase inhibitor that has no intrinsic antimicrobial activity but prevents breakdown of beta lactam by beta lactamase enzyme.

Clinical Use

    • Indications
    • Community-acquired pneumonia
    • Peritonsillar abscess
    • Bacterial endocarditis
    • Rheumatic fever
    • Syphilis
    • Adverse Effects
    • Hypersensitivity - urticarial rash, oedema, anaphylaxis
    • GIT - nausea / vomiting / diarrhoea
    • Thrombocytopaenia / leukopaenia

Potential Indications
BETA

Acute Rheumatic Fever
Infective Endocarditis
Syphilis
Peritonsillar abscess
Pneumonia

Associated Adverse Effects
BETA

Anaphylaxis
Anaphylaxis
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