IV
Piperacillin-Tazobactam
PipTaz, Tazosin
Used for severe infections only
- Mechanism of Action
- Piperacillin is a beta lactam antibiotic that inhibits bacterial cell wall synthesis. Tazobactam is a a beta lactamase inhibitor that has no intrinsic antimicrobial activity but prevents breakdown of beta lactam by beta lactamase enzyme.
Clinical Use
- Indications
- Community-acquired pneumonia
- Peritonsillar abscess
- Bacterial endocarditis
- Rheumatic fever
- Syphilis
- Adverse Effects
- Hypersensitivity - urticarial rash, oedema, anaphylaxis
- GIT - nausea / vomiting / diarrhoea
- Thrombocytopaenia / leukopaenia
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