Physostigmine
- IV / IMPhysostigmine
Mechanism of Action
- Inhibits acetylcholinesterase, resulting in reduced breakdown of acetylcholine which overcomes anticholinergic agents' competitive inhibition of nicotinic and muscarinic receptors.
Pharmacology
- Crosses the blood-brain barrier, therefore able to counteract the central effects of anticholinergics.
Clinical Use
Indications
- Anticholinergic toxicity, due to agents such as atropine, scopolamine or benztropine.
- Adverse Effects
- Nausea / vomiting
- Salivation
- Bradycardia
- Convulsions