Physostigmine

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    IV / IM
    Physostigmine

    • Mechanism of Action
    • Inhibits acetylcholinesterase, resulting in reduced breakdown of acetylcholine which overcomes anticholinergic agents’ competitive inhibition of nicotinic and muscarinic receptors.
    • Pharmacology
    • Crosses the blood-brain barrier, therefore able to counteract the central effects of anticholinergics.

Clinical Use

    • Indication
    • Anticholinergic toxicity, due to agents such as atropine, scopolamine or benztropine.
    • Adverse Effects
    • Nausea / vomiting
    • Salivation
    • Bradycardia
    • Convulsions
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