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Drug Guide
 
 

Physostigmine

 
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    IV / IM
    Physostigmine

  • Mechanism of Action

  • Inhibits acetylcholinesterase, resulting in reduced breakdown of acetylcholine which overcomes anticholinergic agents’ competitive inhibition of nicotinic and muscarinic receptors.
  • Pharmacology

  • Crosses the blood-brain barrier, therefore able to counteract the central effects of anticholinergics.

Clinical Use

  • Indications

  • Anticholinergic toxicity, due to agents such as atropine, scopolamine or benztropine.
  • Adverse Effects
  • Nausea / vomiting
  • Salivation
  • Bradycardia
  • Convulsions
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