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Drug Guide
 
 

Phenelzine

 
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 View Topic Outline
  •  
    Oral
    Phenelzine
    Nardil 

  • Mechanism of Action

  • Inhibits the activity of monoamine oxidase, responsible for breakdown of monoamines. Inhibition results in increased synaptic noradrenaline, dopamine and serotonin.

Clinical Use

  • Indications

  • Depression refractory to more commonly used medications.

  • Contraindications

  • Not for concurrent use with selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) or tricyclic antidepressants (TCAs).
  • Adverse Effects
  • Dry mouth
  • Constipation
  • Dizziness / headache
  • Drowsiness
  • Elevated LFTs
  • Weight gain
  • Sexual dysfunction
  • Postural hypotension
  • Serotonin syndrome (when MAOis given with SSRIs / SNRIs) - confusion, agitation, ataxia, hyperreflexia, fevers, diaphoresis
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