Pertuzumab | Drug Guide - MedSchool
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Pertuzumab

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    IV infusion
    Pertuzumab
    Inhibits ligand-dependent HER2 dimerisation and signalling
    • Mechanism of Action
    • A monoclonal antibody directed against the HER2 receptor, which is involved in cell signalling and is overexpressed in certain cancers. Inhibition of HER2 signalling pathways results in cell cycle arrest; the monoclonal antibody also mediates antibody-dependent cell-mediated cytotoxicity.

Clinical Use

    • Indication
    • HER2 positive breast cancer
    • Adverse Effects
    • Cardiac dysfunction
    • Bone marrow suppression – leucopaenia, anaemia, thrombocytopaenia
    • Immunosuppression (susceptibility to infection)
    • Nausea / vomiting / diarrhoea
    • Abdominal pain
    • Dyspnoea / wheeze
    • Peripheral neuropathy
    • Arthralgias / myalgias
    • Headache
    • Dizziness
    • Flushing
    • Weight loss
    • Insomnia
    • Rash
 
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