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Drug Guide
 
 

Perindopril Arginine

 
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    Oral
    Perindopril Arginine
    Coversyl 
  • Mechanism of Action
  • Inhibits the ACE-driven conversion of angiotensin I to angiotensin II.
  • Causes vascular smooth muscle relaxation, reduced tubular sodium and water reabsorption, reduced aldosterone secretion, reduced ADH secretion and water retention, and increased bradykinin.

Clinical Use

  • Indications
  • Hypertension – first line management, especially in patients with chronic kidney disease or heart failure
  • Heart failure
  • Post myocardial infarction
  • Contraindications
  • Renal artery stenosis (precipitates renal failure)
  • Pregnancy
  • Adverse Effects
  • Dry Cough (due to bradykinin)
  • Hypotension
  • Angioedema
  • Hyperkalaemia
  • Renal impairment
  • Monitoring

  • Electrolytes, urea and creatinine.
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