- Mechanism of Action
- Inhibits multiple receptor tyrosine kinases involved in tumour growth, angiogenesis and metastasis.
- Pharmacology
- Many off-target effects due to inhibition of multiple targets.
Clinical Use
- Indications
- Advanced renal cell carcinoma
- Advanced soft tissue sarcoma
- Adverse Effects
- Fatigue
- Anorexia
- Mucositis
- Diarrhoea
- Cardiotoxicity - CCF, MI, thromboembolism, hypertension
- Hypothyroidism
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