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Pazopanib

  •  
    Oral
    Pazopanib
    Votrient 
    • Mechanism of Action
    • Inhibits multiple receptor tyrosine kinases involved in tumour growth, angiogenesis and metastasis.
    • Pharmacology
    • Many off-target effects due to inhibition of multiple targets.

Clinical Use

    • Indications
    • Advanced renal cell carcinoma
    • Advanced soft tissue sarcoma
    • Adverse Effects
    • Fatigue
    • Anorexia
    • Mucositis
    • Diarrhoea
    • Cardiotoxicity - CCF, MI, thromboembolism, hypertension
    • Hypothyroidism

Potential Indications
BETA

Associated Adverse Effects
BETA

Haemodynamic Dysfunction
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