Paracetamol / Acetaminophen
- Oral / IVParacetamol / AcetaminophenPanadol, Tylenol, Dymadon, Panadol Osteo (SR)
Mechanism of Action
- Unknown mechanism, though believed to be a weak inhibitor of prostaglandin synthesis. Also thought to inhibit COX-2, though without anti-inflammatory effects.
- Adverse Effects
- Liver toxicity can occur if doses greater than 10g or 200mg/kg (whichever is lower) are ingested within a 24-hour period.
- May be reversed with N-acetylcysteine (NAC).