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Paracetamol / Acetaminophen

  •  
    Oral / IV
    Paracetamol / Acetaminophen
    Panadol, Tylenol, Dymadon, Panadol Osteo (SR) 
    • Mechanism of Action
    • Unknown mechanism, though believed to be a weak inhibitor of prostaglandin synthesis. Also thought to inhibit COX-2, though without anti-inflammatory effects.

Clinical Use

    • Indications
    • Pain
    • Fever
    • Adverse Effects
    • Rare.
    • Liver toxicity can occur if doses greater than 10g or 200mg/kg (whichever is lower) are ingested within a 24-hour period.
    • May be reversed with N-acetylcysteine (NAC).
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