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Drug Guide


    • Mechanism of Action
    • A monoclonal antibody directed against epidermal growth factor receptor (EGFR / HER1), which is involved in cell signalling and is overexpressed in certain cancers. Inhibition of EGFR signalling pathways results in cell cycle arrest.

Clinical Use

    • Indication
    • Metastatic colorectal cancer that is EGFR positive, RAS wild type
    • Contraindications
    • May not be used in the presence of RAS or BRAF mutations (must be wild type).
    • Adverse Effects
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