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Paliperidone

  •  
    Oral / IM
    Paliperidone
    Invega 
     
    Available as depot – monthly dosing for schizophrenia
    • Mechanism of Action
    • Seems to cause transient antagonism of D2 receptors, as well as serotonin 5-HT2A antagonism.
    • Pharmacology
    • Less extrapyramidal adverse effects and less hyperprolactinaemia than first generation antipsychotics.

Clinical Use

    • Indications
    • Psychosis – schizophrenia, and related disorders
    • Acute mania
    • Adverse Effects
    • Drowsiness
    • Postural hypotension
    • Prolonged QTc
    • Dyslipidaemia
    • Weight gain
    • Anticholinergic – dry mouth, blurred vision, constipation, urinary retention, delirium
    • Extrapyramidal – dystonia, akathisia, parkinsonism, tardive dyskinesia
    • Hyperprolactinaemia – gynaecomastia, galactorrhoea, infertility, sexual dysfunction

Potential Indications
BETA

Mania
Schizoaffective Disorder
Schizophrenia

Associated Adverse Effects
BETA

Endocrinology
Pituitary Pathology
Male Sexual
Male Infertility
Male Infertility
Neurological
Secondary Parkinsonism
Secondary Parkinsonism
Delirium
Delirium
Nutrition & Metabolic
Secondary Hyperlipidaemia
Secondary Hyperlipidaemia
Obstetrics & Gynaecology
Gynaecology
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