Drug Guide
 

Palbociclib

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    Oral
    Palbociclib
    Ibrance 
    • Mechanism of Action
    • Selectively inhibits cyclin-dependent kinase (CDK) 4 and 6, which act downstream of multiple mitogenic signalling pathways to stimulate cell proliferation.

Clinical Use

    • Indication
    • HER2 negative, ER / PR positive advanced or metastatic breast cancer in men or postmenopausal women (in combination with an aromatase inhibitor).
    • Adverse Effects
    • Neutropaenia (~75% of cases)
    • Nausea / vomiting / diarrhoea
    • Fatigue
    • Alopecia
    • Rash
    • LFT derangement
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