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Drug Guide
 
 

Palbociclib

 
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  •  
    Oral
    Palbociclib
    Ibrance 

  • Mechanism of Action

  • Selectively inhibits cyclin-dependent kinase (CDK) 4 and 6, which act downstream of multiple mitogenic signalling pathways to stimulate cell proliferation.

Clinical Use

  • Indications

  • HER2 negative, ER / PR positive advanced or metastatic breast cancer in men or postmenopausal women (in combination with an aromatase inhibitor).
  • Adverse Effects
  • Neutropaenia (~75% of cases)
  • Nausea / vomiting / diarrhoea
  • Fatigue
  • Alopecia
  • Rash
  • LFT derangement
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