Palbociclib
- OralPalbociclibIbrance
- Mechanism of Action
- Selectively inhibits cyclin-dependent kinase (CDK) 4 and 6, which act downstream of multiple mitogenic signalling pathways to stimulate cell proliferation.
Clinical Use
- Indication
- HER2 negative, ER / PR positive advanced or metastatic breast cancer in men or postmenopausal women (in combination with an aromatase inhibitor).
- Adverse Effects