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Paclitaxel

  •  
    IV
    Paclitaxel
    Taxol 
     
    Inhibits the cell cycle at the G2-M phase junction
    • Mechanism of Action
    • Prevents cellular proliferation by binding to the beta unit of tubulin and inhibiting microtubule polymerization.

Clinical Use

    • Indication
    • Certain solid organ malignancies, as guided by cancer specialists and local guidelines.
    • Adverse Effects
    • Bone marrow suppression - neutropaenia / anaemia / thrombocytopaenia
    • Oedema
    • Peripheral neuropathy
    • Nausea / vomiting / diarrhea
    • Elevated LFTs
    • Rash
    • Alopecia
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