Paclitaxel

• Mechanism of Action
• Prevents cellular proliferation by binding to the beta unit of tubulin and inhibiting microtubule polymerization.

Clinical Use

• • Indication
  • Certain solid organ malignancies, as guided by cancer specialists and local guidelines.
• • Adverse Effects
  • Bone marrow suppression - neutropaenia / anaemia / thrombocytopaenia
  • Oedema
  • Peripheral neuropathy
  • Nausea / vomiting / diarrhea
  • Elevated LFTs
  • Rash
  • Alopecia