Oxycodone + Naloxone

 
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    Oral
    Oxycodone + Naloxone
    Targin 
     
    Includes a reversal agent, to reduce adverse effects (particularly constipation)
    • Mechanism of Action
    • Oxcodone is an opioid, which acts on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.Naloxone is a competitive antagonist of μ, κ, and δ opioid receptors, reversing the action of exogenous opioids.
    • Pharmacology
    • Less histamine release (flushing, itching, rash) and less constipating than natural opioids.

Clinical Use

    • Indication
    • Acute and chronic pain
    • Adverse Effects
    • Less than with other opioids
      Nausea / vomiting
    • Constipation
    • Sedation
    • Respiratory depression
    • Diaphoresis
    • Delirium
    • Hypersensitivity – bronchospasm, urticaria
    • Bradycardia
    • Tolerance
    • Dependence
    • Hypogonadism
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