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Oxycodone + Naloxone

 
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 View Topic Outline
  •  
    Oral
    Oxycodone + Naloxone
    Targin 
     
    Includes a reversal agent, to reduce adverse effects (particularly constipation)

  • Mechanism of Action

  • Oxcodone is an opioid, which acts on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.Naloxone is a competitive antagonist of μ, κ, and δ opioid receptors, reversing the action of exogenous opioids.

  • Pharmacology

  • Less histamine release (flushing, itching, rash) and less constipating than natural opioids.

Clinical Use

  • Indications

  • Acute and chronic pain
  • Adverse Effects
  • Less than with other opioids
    Nausea / vomiting
  • Constipation
  • Sedation
  • Respiratory depression
  • Diaphoresis
  • Delirium
  • Hypersensitivity – bronchospasm, urticaria
  • Bradycardia
  • Tolerance
  • Dependence
  • Hypogonadism
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