- OralOxycodoneEndone, Oxycontin (SR)Better tolerated than morphine / codeine
Mechanism of Action
- Acts on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.
- Less histamine release (flushing, itching, rash) and less constipating than natural opioids.
- Acute and chronic pain
- Adverse Effects
- Nausea / vomiting
- Respiratory depression
- Hypersensitivity – bronchospasm, urticaria