Mechanism of Action
- An alkylating agent that binds to DNA, causing intrastrand and interstrand crosslinks that change DNA conformation and affect replication.
- Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
- Adverse Effects
- Bone marrow suppression - leucopaenia, thrombocytopaenia, anaemia
- Renal dysfunction
- Nausea / vomiting
- Elevated LFTs
- Ototoxicity - tinnitus, hearing loss
- Transient loss of vision
- Peripheral neuropathy