Login or Register to unlock everything MedSchool has to offer!

#

A

B

C

D

E

F

G

H

I

K

L

M

N

O

P

Q

R

S

T

U

V

W

Z

 

Osimertinib

  •  
    Oral
    Osimertinib
    Tagrisso 
     
    May be used in patients with T790M mutations which would otherwise confer resistance to other generations of EGFR inhibitors
    • Mechanism of Action
    • Inhibits epidermal growth factor receptor (EGFR), a transmembrane amino acid receptor tyrosine kinase found in approximately 15% of non small cell lung cancers.
      EGFR mutations affect downstream signalling pathways resulting in cell proliferation
      Inhibition of these receptors disrupts this proliferation pathway.

Clinical Use

    • Indication
    • Advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR mutation
    • Adverse Effects
    • Acneiform rash
    • Diarrhoea
    • Ocular changes
    • Alopecia
    • Nail changes
    • Interstitial lung disease

Potential Indications
BETA

Lung Cancer
Feedback