- Mechanism of Action
- Inhibits poly ADP ribose polymerase (PARP) enzymes that repair single strand DNA breaks, resulting in DNA double strand breaks.
- In normal (BRCA wildtype) cells, these are repaired by homologous functional repair which requires functional BRCA genes.
- In BRCA (1 / 2) gene mutations (germline or somatic), these breaks are not repaired which results in genomic instability and cell death.
- BRCA-mutated high grade serous ovarian, fallopian tube or primary peritoneal cancer that has responded to platinum-based themotherapy.
- Adverse Effects