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Drug Guide


  • Mechanism of Action
  • Inhibits poly ADP ribose polymerase (PARP) enzymes that repair single strand DNA breaks, resulting in DNA double strand breaks.
  • In normal (BRCA wildtype) cells, these are repaired by homologous functional repair which requires functional BRCA genes.
  • In BRCA (1 / 2) gene mutations (germline or somatic), these breaks are not repaired which results in genomic instability and cell death.

Clinical Use

  • Indications

  • BRCA-mutated high grade serous ovarian, fallopian tube or primary peritoneal cancer that has responded to platinum-based themotherapy.
  • Adverse Effects
  • Nausea
  • Fatigue
  • Myelosuppression
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