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Drug Guide


    Binds both active & inactive conformation of Bcr-Abl kinase, resulting in reduced resistance
  • Mechanism of Action

  • Inhibits the Bcr-Abl tyrosine kinase as well as the stem cell receptor factor (cKIT) and several other receptor tyrosine kinases.

Clinical Use

  • Indications

  • Philadelphia chromosome positive chronic myeloid leukaemia in the chronic phase or with resistance or intolerance to imatinib
  • Adverse Effects
  • Rash
  • Fatigue
  • Oedema
  • Nausea / vomiting / diarrhoea
  • Muscle cramping
  • Peripheral neuropathy
  • LFT derangement
  • Myelosuppression - anaemia, neutropaenia, thrombocytopaenia
  • Cardiovascular - cardiac ischaemia, stroke, peripheral vascular disease, hypercholesterolaemia
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