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Drug Guide


    β1 antagonism, as well as vasodilatation due to increased endothelial NO release
  • Mechanism of Action
  • Selectively and competitively inhibit the action of adrenaline and noradrenaline on β1, resulting in suppression of the sympathetic nervous system.
  • Also stimulates release of nitric oxide (NO) from the endothelium, resulting in vasodilatation.

Clinical Use

  • Indications

  • Hypertension - second-line therapy, especially indicated for patients with stable angina or post MI.Stable heart failure
  • Contraindications
  • Asthma
  • Decompensated heart failure
  • AV block
  • Adverse Effects
  • Fatigue / headache
  • Bradycardia
  • Postural hypotension
  • Nausea / vomiting / diarrhoea
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