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Natalizumab

 
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  •  
    IV
    Natalizumab
    Tysabri 

  • Mechanism of Action

  • Monoclonal antibody toward leucocyte adhesion molecules, resulting in slowed entry of T cells into the CNS.

Clinical Use

  • Indications

  • Relapsing-remitting multiple sclerosis (MS).
  • Contraindications
  • Other immunomodulatory agents
  • Immunocompromised patients
  • Adverse Effects
  • Progressive multifocal leukencephalopathy (PML)
  • Headache
  • Fatigue
  • Arthralgia
  • Increased risk of infection
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