Naproxen
- OralNaproxen14 hour half-life
Mechanism of Action
- Inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
Pharmacology
- Competitively and non-selectively binds to COX.
Clinical Use
- Indications
- Pain – including migraine and musculoskeletal injury
- Fever
- Inflammation – especially associated with arthritides
- Adverse Effects
- Gastritis / peptic ulceration
- Nephrotoxicity
- Hypertension / fluid retention / congestive cardiac failure / MI
- Hypersensitivity reactions
- Delirium
- Headache
- Elevated LFTs
- Neutropaenia