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Naproxen

  •  
    Oral
    Naproxen
    14 hour half-life
    • Mechanism of Action
    • Inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
    • Pharmacology
    • Competitively and non-selectively binds to COX.

Clinical Use

    • Indications
    • Pain – including migraine and musculoskeletal injury
    • Fever
    • Inflammation – especially associated with arthritides
    • Adverse Effects
    • Gastritis / peptic ulceration
    • Nephrotoxicity
    • Hypertension / fluid retention / congestive cardiac failure / MI
    • Hypersensitivity reactions
    • Delirium
    • Headache
    • Elevated LFTs
    • Neutropaenia

Potential Indications
BETA

Associated Adverse Effects
BETA

Gut
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