Mechanism of Action
- A competitive antagonist of Î¼, Îº, and Î´ opioid receptors, reversing the action of exogenous opioids.
- Opioid overdose associated with sedation and/or respiratory depression
- In combination with oral oxycodone â€“ to reduce GI side effects
- Opioid withdrawal â€“ nausea, vomiting, diaphoresis, tachycardia, tremor, seizure.