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Drug Guide
 
 

Naloxone

 
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  •  
    IV
    Naloxone
    Narcan 

  • Mechanism of Action

  • A competitive antagonist of μ, κ, and δ opioid receptors, reversing the action of exogenous opioids.

Clinical Use

  • Indications
  • Opioid overdose associated with sedation and/or respiratory depression
  • In combination with oral oxycodone – to reduce GI side effects

  • Adverse Effects

  • Opioid withdrawal – nausea, vomiting, diaphoresis, tachycardia, tremor, seizure.
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