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Naloxone

  •  
    IV
    Naloxone
    Narcan 
    • Mechanism of Action
    • A competitive antagonist of μ, κ, and δ opioid receptors, reversing the action of exogenous opioids.

Clinical Use

    • Indications
    • Opioid overdose associated with sedation and/or respiratory depression
    • In combination with oral oxycodone – to reduce GI side effects
    • Adverse Effects
    • Opioid withdrawal – nausea, vomiting, diaphoresis, tachycardia, tremor, seizure.

Potential Indications
BETA

Opioid Toxicity

Associated Adverse Effects
BETA

Opioid Withdrawal
Opioid Withdrawal
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