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N-Acetylcysteine

 
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    IV
    N-Acetylcysteine
    Acetadote 

  • Mechanism of Action

  • Provides cysteine for use in the synthesis of glutathione, which facilitates metabolism of the toxic paracetamol metabolite N-acetyl-p-benzoquinoneimine.

Clinical Use

  • Indications

  • Severe paracetamol / acetaminophen overdose.
  • Adverse Effects
  • Hypersensitivity - rash, oedema, bronchospasm, anaphylaxis
  • Nausea / vomiting
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