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Mycophenolate Mofetil

  •  
    Oral / IV
    Mycophenolate Mofetil
    CellCept, Myfortic 
    • Mechanism of Action
    • A prodrug of mycophenolic acid (MPA), a non-competitive, reversible inhibitor of inosine monophosphate dehydrogenase (IMPD). IMPD is a key enzyme in the synthesis of guanosine triphosphate; T cells and B cells are critically dependent on this pathway and thus its inhibition results in impaired lymphocyte proliferation.

Clinical Use

    • Indications
    • Prevention of graft rejection following kidney, liver or heart transplantation
    • Lupus nephritis (class III, IV or V)
    • Adverse Effects
    • Malignancies (particularly lymphoma, skin cancers)
    • Opportunistic infections
    • Leukopaenia, anaemia, thrombocytopaenia
    • Headache
    • Pulmonary fibrosis
    • Nausea / vomiting / diarrhoea
    • LFT derangement
    • Arthralgias / myalgias

Potential Indications
BETA

Lupus Nephritis

Associated Adverse Effects
BETA

Drug-Induced Pulmonary Fibrosis
Drug-Induced Pulmonary Fibrosis
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