Mycophenolate Mofetil
- Oral / IVMycophenolate MofetilCellCept, Myfortic
Mechanism of Action
- A prodrug of mycophenolic acid (MPA), a non-competitive, reversible inhibitor of inosine monophosphate dehydrogenase (IMPD). IMPD is a key enzyme in the synthesis of guanosine triphosphate; T cells and B cells are critically dependent on this pathway and thus its inhibition results in impaired lymphocyte proliferation.
Clinical Use
- Indications
- Prevention of graft rejection following kidney, liver or heart transplantation
- Lupus nephritis (class III, IV or V)
- Adverse Effects
- Malignancies (particularly lymphoma, skin cancers)
- Opportunistic infections
- Leukopaenia, anaemia, thrombocytopaenia
- Headache
- Pulmonary fibrosis
- Nausea / vomiting / diarrhoea
- LFT derangement
- Arthralgias / myalgias