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Drug Guide

Mycophenolate Mofetil

    Oral / IV
    Mycophenolate Mofetil
    CellCept, Myfortic 
  • Mechanism of Action

  • A prodrug of mycophenolic acid (MPA), a non-competitive, reversible inhibitor of inosine monophosphate dehydrogenase (IMPD). IMPD is a key enzyme in the synthesis of guanosine triphosphate; T cells and B cells are critically dependent on this pathway and thus its inhibition results in impaired lymphocyte proliferation.

Clinical Use

  • Indications
  • Prevention of graft rejection following kidney, liver or heart transplantation
  • Lupus nephritis (class III, IV or V)
  • Adverse Effects
  • Malignancies (particularly lymphoma, skin cancers)
  • Opportunistic infections
  • Leukopaenia, anaemia, thrombocytopaenia
  • Headache
  • Pulmonary fibrosis
  • Nausea / vomiting / diarrhoea
  • LFT derangement
  • Arthralgias / myalgias
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