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Moxifloxacin

  •  
    Oral / IV
    Moxifloxacin
    Avelox 
     
    Useful for pneumonia in patients with severe penicillin / cephalosporin allergy, due to Staph and atypical cover
    • Mechanism of Action
    • Inhibits DNA gyrase, preventing supercoiling of DNA and disrupting cell division.
    • Microbiology
    • Broad spectrum including Staphylococcus aureus and atypical respiratory organisms (Legionella, Chlamydia, Mycoplasma). No activity against Pseudomonas.

Clinical Use

    • Indications
    • Gastroenteritis (empirical agents of choice)
    • Genitourinary infections - UTI, PID, bacterial prostatitis
    • Skin infections
    • Osteomyelitis / septic arthritis
    • Anthracosis
    • Adverse Effects
    • Nausea, vomiting, diarrhoea
    • Headache / dizziness / fatigue
    • QT prolongation
    • Tendinopathy (in children)

Potential Indications
BETA

Infective Gastroenteritis
Anthrax
Prostatitis
Septic Arthritis
Osteomyelitis
Pelvic Inflammatory Disease
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