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Drug Guide
 
 

Moxifloxacin

 
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  •  
    Oral / IV
    Moxifloxacin
    Avelox 
     
    Useful for pneumonia in patients with severe penicillin / cephalosporin allergy, due to Staph and atypical cover

  • Mechanism of Action

  • Inhibits DNA gyrase, preventing supercoiling of DNA and disrupting cell division.

  • Microbiology

  • Broad spectrum including Staphylococcus aureus and atypical respiratory organisms (Legionella, Chlamydia, Mycoplasma). No activity against Pseudomonas.

Clinical Use

  • Indications
  • Gastroenteritis (empirical agents of choice)
  • Genitourinary infections - UTI, PID, bacterial prostatitis
  • Skin infections
  • Osteomyelitis / septic arthritis
  • Anthracosis
  • Adverse Effects
  • Nausea, vomiting, diarrhoea
  • Headache / dizziness / fatigue
  • QT prolongation
  • Tendinopathy (in children)
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