- Oral / Rectal / IV / IM / SubcutMorphineKapanol, MS Contin (SR)Predominant µ receptor selectivity
Good absorption but significant first-pass metabolism – bioavailability of 30%
- Mechanism of Action
- Acts on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.
- Acute and chronic pain
- Adverse Effects