• Mechanism of Action
• Inhibits the activity of monoamine oxidase, responsible for breakdown of monoamines. Inhibition results in increased synaptic noradrenaline, dopamine and serotonin.

Clinical Use

• • Indication
  • Depression refractory to more commonly used medications.
• • Contraindications
  • Not for concurrent use with selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) or tricyclic antidepressants (TCAs).
• • Adverse Effects