Moclobemide | Drug Guide - MedSchool
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Moclobemide

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    Oral
    Moclobemide

    • Mechanism of Action
    • Inhibits the activity of monoamine oxidase, responsible for breakdown of monoamines. Inhibition results in increased synaptic noradrenaline, dopamine and serotonin.

Clinical Use

    • Indication
    • Depression refractory to more commonly used medications.
    • Contraindications
    • Not for concurrent use with selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) or tricyclic antidepressants (TCAs).
    • Adverse Effects
    • Dry mouth
    • Constipation
    • Dizziness / headache
    • Drowsiness
    • Elevated LFTs
    • Weight gain
    • Sexual dysfunction
    • Postural hypotension
    • Serotonin syndrome (when MAOis given with SSRIs / SNRIs) – confusion, agitation, ataxia, hyperreflexia, fevers, diaphoresis
 
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