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Mitoxantrone

  •  
    IV
    Mitoxantrone

    • Mechanism of Action
    • Unknown, though appears to inhibit DNA synthesis through inhibition of topoisomerase II.

Clinical Use

    • Indications
    • Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines
    • Multiple sclerosis
    • Adverse Effects
    • Bone marrow suppression – leucopaenia / anaemia / thrombocytopaenia
    • Nausea / vomiting
    • Stomatitis
    • Alopecia
    • Blue / green discolouration of urine

Potential Indications
BETA

Multiple Sclerosis
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