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Drug Guide
 
 

Mitoxantrone

 
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    Mitoxantrone

  • Mechanism of Action

  • Unknown, though appears to inhibit DNA synthesis through inhibition of topoisomerase II.

Clinical Use

  • Indications
  • Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines
  • Multiple sclerosis
  • Adverse Effects
  • Bone marrow suppression – leucopaenia / anaemia / thrombocytopaenia
  • Nausea / vomiting
  • Stomatitis
  • Alopecia
  • Blue / green discolouration of urine
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