IV
Mitomycin
Activity is not cell-cycle specific
- Mechanism of Action
- Binds to DNA, resulting in prevention of RNA transcription and protein synthesis.
- Pharmacology
- Bone marrow-sparing, therefore often used when other antineoplastics are contraindicated.
Clinical Use
- Indication
- Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
- Adverse Effects
- Nausea / vomiting / diarrhoea / anorexia
- Pneumonitis
- Alopecia
- Soft tissue damage (if extravasation)
- Monitoring
- Lung function.
Want more info like this?
- Your electronic clinical medicine handbook
- Guides to help pass your exams
- Tools every medical student needs
- Quick diagrams to have the answers, fast
- Quizzes to test your knowledge
Explore