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Mifepristone (RU486)

  •  
    Oral
    Mifepristone (RU486)
    Given initially to prepare the genitourinary tract
    • Mechanism of Action
    • Competitively inhibit the action of progesterone and glucocorticoid on their receptors. Results in endometrial degeneration, cervical dilatation, prostaglandin release, reduced progesterone release and reduced β-HCG production.

Clinical Use

    • Indication
    • Preparation of the genital tract for medical abortion.
    • Contraindications
    • Bleeding disorder / anticoagulants
    • Uncertainty about age of pregnancy
    • Suspected ectopic pregnancy
    • Adverse Effects
    • Uterine contractions
    • Per vaginal bleeding
    • Headache
    • Dizziness
    • Nausea / vomiting / diarrhoea
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