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Drug Guide
 
 

Metronidazole

 
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    Oral / IV / PR
    Metronidazole
    Flagyl 
  • Mechanism of Action

  • Broken down into its active form selectively by anaerobic and protozoal cells. Binds to and disrupts DNA, resulting in DNA degradation and cell death.
  • Microbiology

  • Good anaerobic cover (e.g. Clostridium spp, Bacteroides fragilis), with additional activity against protozoa such as Trichomonas vagilanis, Giardia lamblia and Entamoeba histolytica.

Clinical Use

  • Indications
  • Anaerobic and protozoal infections:
  • Bacteria - intra-abdominal sepsis, Clostridium difficile diarrhoea, bacterial vaginosis
  • Protozoa - giardiasis, amoebiasis, trichomoniasis
  • Adverse Effects
  • Disulfuram-like effect (severe ‘hangover’ with alcohol)
  • Nausea, vomiting
  • Headache
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