Drug Guide
 

Metronidazole

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    Oral / IV / PR
    Metronidazole
    Flagyl 
    • Mechanism of Action
    • Broken down into its active form selectively by anaerobic and protozoal cells. Binds to and disrupts DNA, resulting in DNA degradation and cell death.
    • Microbiology
    • Good anaerobic cover (e.g. Clostridium spp, Bacteroides fragilis), with additional activity against protozoa such as Trichomonas vagilanis, Giardia lamblia and Entamoeba histolytica.

Clinical Use

    • Indications
    • Anaerobic and protozoal infections:
    • Bacteria - intra-abdominal sepsis, Clostridium difficile diarrhoea, bacterial vaginosis
    • Protozoa - giardiasis, amoebiasis, trichomoniasis
    • Adverse Effects
    • Disulfuram-like effect (severe ‘hangover’ with alcohol)
    • Nausea, vomiting
    • Headache
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