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Drug Guide
 
 

Methotrexate

 
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    Oral / IV
    Methotrexate
    Weekly dosing
    • Mechanism of Action
    • Inflammatory diseases: inhibits interleukin-1 and interleukin 6 activity, and altering the numbers of different lymphocyte subsets.
      In cancer treatment: inhibits dihydrofolate reductase (DHFR), reducing synthesis of folate, which is involved in synthesis of the purine and pyramidine precursors required for DNA / RNA and cell proliferation.
    • Pharmacology

Clinical Use

    • Indications
    • Adverse Effects
    • Monitoring
    • Monthly full blood count, renal function and LFTs.
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