- Oral / IVMethotrexateWeekly dosing
- Mechanism of Action
- Inflammatory diseases: inhibits interleukin-1 and interleukin 6 activity, and altering the numbers of different lymphocyte subsets.
In cancer treatment: inhibits dihydrofolate reductase (DHFR), reducing synthesis of folate, which is involved in synthesis of the purine and pyramidine precursors required for DNA / RNA and cell proliferation.
- Adverse Effects
- Monthly full blood count, renal function and LFTs.