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Drug Guide
 
 

Methadone

 
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  •  
    Oral / IV
    Methadone
    Dolophine 
     
    Used for long-term treatment of opioid addiction

  • Mechanism of Action

  • Acts on opioid receptors (δ, κ and μ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.

Clinical Use

  • Indications

  • Opioid addiction
  • Adverse Effects
  • Nausea / vomiting
  • Constipation
  • Sedation
  • Respiratory depression
  • Diaphoresis
  • Delirium
  • Hypersensitivity - bronchospasm, urticaria
  • Bradycardia
  • Tolerance
  • Dependence
  • Hypogonadism
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