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Drug Guide
 
 

Metformin

 
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    Oral
    Metformin
    Diabex, Diaformin 
     
    Reduce dose in renal insufficiency
  • Mechanism of Action
  • Inhibits hepatic gluconeogenesis
  • Reduces intestinal absorption of glucose
  • Stimulates peripheral glucose uptake

Clinical Use

  • Indications
  • Glycaemic control for type II diabetes - first line
  • Gestational diabetes mellitus
  • Polycystic ovarian syndrome (PCOS) with menstrual irregularity
  • Contraindications

  • Renal failure with eGFR <30mL/min.
  • Adverse Effects
  • Nausea / vomiting / diarrhea
  • Lactic acidosis
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