Metformin

• Mechanism of Action
• Inhibits hepatic gluconeogenesis
  Reduces intestinal absorption of glucose
  Stimulates peripheral glucose uptake

Clinical Use

• • Indications
  • Glycaemic control for type II diabetes - first line
  • Gestational diabetes mellitus
  • Polycystic ovarian syndrome (PCOS) with menstrual irregularity
• • Contraindications
  • Renal failure with eGFR <30mL/min.
• • Adverse Effects
  • Nausea / vomiting / diarrhea
  • Lactic acidosis