Drug Guide
 

Mesalazine

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    Oral / Rectal
    Mesalazine
    Salofalk 
    • Mechanism of Action
    • Inhibits 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) transformylase, which results in increased adenosine release at the inflamed site. Adenosine binds to A2 receptors on inflammatory cells resulting in reduced inflammation.

Clinical Use

    • Indication
    • Acute episodes and maintenance of inflammatory bowel disease
    • Adverse Effects
    • CNS - headache
    • Gastrointestinal - abdominal pain / nausea / vomiting / diarrhoea
    • Worsening of ulcerative colitis
    • Hepatotoxicity - elevated LFTs
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