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Drug Guide


    Oral / Rectal
  • Mechanism of Action

  • Inhibits 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) transformylase, which results in increased adenosine release at the inflamed site. Adenosine binds to A2 receptors on inflammatory cells resulting in reduced inflammation.

Clinical Use

  • Indications

  • Acute episodes and maintenance of inflammatory bowel disease
  • Adverse Effects
  • CNS - headache
  • Gastrointestinal - abdominal pain / nausea / vomiting / diarrhoea
  • Worsening of ulcerative colitis
  • Hepatotoxicity - elevated LFTs
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