Login or Register to unlock everything MedSchool has to offer!
Full Drug List
 

#

A

B

C

D

E

F

G

H

I

K

N

O

P

Q

R

S

T

U

V

W

Z

 
 

Mesalazine

  •  
    Oral / Rectal
    Mesalazine
    Salofalk 
    • Mechanism of Action
    • Inhibits 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) transformylase, which results in increased adenosine release at the inflamed site. Adenosine binds to A2 receptors on inflammatory cells resulting in reduced inflammation.

Clinical Use

    • Indication
    • Acute episodes and maintenance of inflammatory bowel disease
    • Adverse Effects
    • CNS - headache
    • Gastrointestinal - abdominal pain / nausea / vomiting / diarrhoea
    • Worsening of ulcerative colitis
    • Hepatotoxicity - elevated LFTs

Potential Indications
BETA

Small & Large Bowel
Feedback