Drug Guide
 

Mefloquine

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    Oral
    Mefloquine
    Lariam 
    • Mechanism of Action
    • Believed to inhibit haem polymerisation, resulting in a buildup of toxic haem molecules into non-toxic haemozoin within the food vacuole of plasmodia.

Clinical Use

    • Indication
    • Acute Plasmodium falciparum infection
    • Contraindications
    • History of seizures, psychosis or cardiac conduction disorders.
    • Adverse Effects
    • Nausea / vomiting
    • Nightmares / depression / psychosis
    • Vertigo
    • Headache
    • Bradycardia
    • Rash
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