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Mefloquine

 
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  •  
    Oral
    Mefloquine
    Lariam 

  • Mechanism of Action

  • Believed to inhibit haem polymerisation, resulting in a buildup of toxic haem molecules into non-toxic haemozoin within the food vacuole of plasmodia.

Clinical Use

  • Indications

  • Acute Plasmodium falciparum infection

  • Contraindications

  • History of seizures, psychosis or cardiac conduction disorders.
  • Adverse Effects
  • Nausea / vomiting
  • Nightmares / depression / psychosis
  • Vertigo
  • Headache
  • Bradycardia
  • Rash
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