Magnesium Sulfate

• Mechanism of Action
• Normalises serum magnesium concentrations in the case of hypomagnesaemia.
  Magnesium is involved in many physiologic processes including cardiac Na⁺ / K⁺ ATPase, and hypomagnesaemia can result in depolarisation and torsades de pointes.
  
  Also stimulates calcium delivery to the sarcoplasmic reticulum and competes with calcium for binding to troponin C, resulting in vasodilation and reduced contractility.

Clinical Use

• • Indications
  • Hypomagnesaemia
  • Severe acute asthma
  • Torsades de pointes
  • Ecclampsia
• • Adverse Effects
  • Due to hypermagnesaemia:
  • Drowsiness
  • Muscle weakness / hyporeflexia
  • Vasodilation / hypotension
  • Blurred vision / diplopia