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Drug Guide
 
 

Magnesium Sulfate

 
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    Oral / IV
    Magnesium Sulfate

    • Mechanism of Action
    • Normalises serum magnesium concentrations in the case of hypomagnesaemia.
    • Magnesium is involved in many physiologic processes including cardiac Na⁺ / K⁺ ATPase, and hypomagnesaemia can result in depolarisation and torsades de pointes.
    • Also stimulates calcium delivery to the sarcoplasmic reticulum and competes with calcium for binding to troponin C, resulting in vasodilation and reduced contractility.

Clinical Use

    • Indications
    • Hypomagnesaemia
    • Severe acute asthma
    • Torsades de pointes
    • Ecclampsia
    • Adverse Effects
    • Due to hypermagnesaemia:
    • Drowsiness
    • Muscle weakness / hyporeflexia
    • Vasodilation / hypotension
    • Blurred vision / diplopia
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