×
MedSchool: Ace Your OSCEsThe Medical Company
 
 
 
 
 
GET - On the App Store
View
Drug Guide
 
 

Lisinopril

 
Bookmark
  •  
    Oral
    Lisinopril
    Zestril 
  • Mechanism of Action
  • Inhibits the ACE-driven conversion of angiotensin I to angiotensin II.
  • Causes vascular smooth muscle relaxation, reduced tubular sodium and water reabsorption, reduced aldosterone secretion, reduced ADH secretion and water retention, and increased bradykinin.

Clinical Use

  • Indications
  • Hypertension - first line management, especially in patients with chronic kidney disease or heart failure
  • Heart failure
  • Post myocardial infarction
  • Contraindications
  • Renal artery stenosis (precipitates renal failure)
  • Pregnancy
  • Adverse Effects
  • Dry Cough (due to bradykinin)
  • Hypotension
  • Angioedema
  • Hyperkalaemia
  • Renal impairment
  • Monitoring

  • Electrolytes, urea and creatinine.
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now
   
 
 

Snapshot: Initialising...