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Drug Guide

Liposomal Amphotericin B

    Liposomal Amphotericin B
    Lipid suspension results in binding directly to the fungal cell, resulting in low doses and significantly less toxicity
  • Mechanism of Action

  • Binds to ergosterol on the cell membrane, resulting in the formation of pores, leakage of cytoplasmic components and cell death.
  • Microbiology

  • Effective against Candida, Cryptococcus and Aspergillus.

Clinical Use

  • Indications
  • Invasive candidiasis
  • Cryptococcal meningitis
  • Aspergillosis
  • Adverse Effects
  • Infusion reactions - fevers, rigors, arthralgias, hypotension, bronchospasm
  • Nephrotoxicity
  • Anaemia
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