Lignocaine

• Mechanism of Action
• Binds to and inhibits neuronal voltage-gated sodium channels, suppressing neuronal depolarization and preventing axonal propagation of action potentials.

Clinical Use

• • Indications
  • Procedural anaesthesia – local anaesthesia, nerve block or epidural block
  • Analgesia – local anaesthesia or epidural block
• • Adverse Effects
  • Hypersensitivity reactions – rash, oedema, anaphylaxis
  • Inadvertent IV administration – agitation, drowsiness, bradycardia, hypotension, ventricular arrhythmia, hyperkalaemia, hypoxia