Local / Regional / Topical / Nasal / IV
Lidocaine / Lignocaine / Xylocaine
- Mechanism of Action
- Bind to and inhibit fast sodium channels responsible for rapid depolarisation during phase 0 of the cardiomyocyte action potential.
- Pharmacology
- Weak sodium channel blockade, and decreases the absolute refractory period (ARP).
Clinical Use
- Indications
- Local anaesthesia / nerve blocks
- Acute ventricular tachycardia
- Torsades de pointes
- Adverse Effects
- Lightheadedness
- Confusion
- Drowsiness
- Bradycardia / hypotension / cardiac arrest
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