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Levodopa + Carbidopa

 
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 View Topic Outline
  •  
    Oral
    Levodopa + Carbidopa
    Sinemet 
  • Mechanism of Action
  • Levodopa - a dopamine precursor that is converted to dopamine, which is severely depleted within the striatum pallidum and substantia nigra in Parkinson’s disease.
  • Benserazide - a decarboxylase inhibitor that inhibits peripheral conversion of levodopa to dopamine.

  • Pharmacology

  • Crosses the blood brain barrier.

Clinical Use

  • Indications

  • Parkinson’s disease.
  • Adverse Effects
  • Involuntary movements
  • Nausea / vomiting
  • Confusion
  • Postural hypotension
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