Levodopa + Carbidopa
- OralLevodopa + CarbidopaSinemet
- Mechanism of Action
- Levodopa - a dopamine precursor that is converted to dopamine, which is severely depleted within the striatum pallidum and substantia nigra in Parkinson’s disease.
- Benserazide - a decarboxylase inhibitor that inhibits peripheral conversion of levodopa to dopamine.
Pharmacology
- Crosses the blood brain barrier.
Clinical Use
Indications
- Parkinson’s disease.
- Adverse Effects
- Involuntary movements
- Nausea / vomiting
- Confusion
- Postural hypotension