Drug Guide
 

Letrozole

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    Oral
    Letrozole

    • Mechanism of Action
    • Selectively inhibits aromatase, preventing aromatization of androgens into oestrogens.

Clinical Use

    • Indication
    • Endocrine therapy for ER positive breast cancer.
    • Contraindications
    • Premenopausal patients (must be postmenopausal).
    • Adverse Effects
    • Hot flushes
    • Vaginal dryness / bleeding
    • Reduced libido
    • Arthralgia / joint stiffness
    • Headache
    • Nausea / vomiting / diarrhoea / anorexia
    • Rash
    • Alopecia
    • Osteopaenia
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