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Drug Guide
 
 

Letrozole

 
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  •  
    Oral
    Letrozole

  • Mechanism of Action

  • Selectively inhibits aromatase, preventing aromatization of androgens into oestrogens.

Clinical Use

  • Indications

  • Endocrine therapy for ER positive breast cancer.

  • Contraindications

  • Premenopausal patients (must be postmenopausal).
  • Adverse Effects
  • Hot flushes
  • Vaginal dryness / bleeding
  • Reduced libido
  • Arthralgia / joint stiffness
  • Headache
  • Nausea / vomiting / diarrhoea / anorexia
  • Rash
  • Alopecia
  • Osteopaenia
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