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Drug Guide
 
 

Leflunomide

 
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  •  
    Oral
    Leflunomide
    Arava 

  • Mechanism of Action

  • Believed to inhibit the mitochondrial enzyme dihydroorotate dehydrogenase, which is involved in pyramidine synthesis.

Clinical Use

  • Indications
  • Active rheumatoid arthritis
  • Active psoriatic arthritis
  • Adverse Effects
  • Nausea / vomiting / diarrhoea
  • Rash
  • Hypertension
  • Elevated LFTs
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