Oral / IM
Stronger but more likely to cause renal failure / peptic ulceration
- Mechanism of Action
- Inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
- Competitively and non-selectively binds to COX.
- Pain – including migraine and musculoskeletal injury
- Inflammation – especially associated with arthritides
- Adverse Effects
- Gastritis / peptic ulceration
- Hypertension / fluid retention / congestive cardiac failure / MI
- Hypersensitivity reactions
- Elevated LFTs
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