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Ketorolac

  •  
    Oral / IM
    Ketorolac
    Stronger but more likely to cause renal failure / peptic ulceration
    • Mechanism of Action
    • Inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
    • Pharmacology
    • Competitively and non-selectively binds to COX.

Clinical Use

    • Indications
    • Pain – including migraine and musculoskeletal injury
    • Fever
    • Inflammation – especially associated with arthritides
    • Adverse Effects
    • Gastritis / peptic ulceration
    • Nephrotoxicity
    • Hypertension / fluid retention / congestive cardiac failure / MI
    • Hypersensitivity reactions
    • Delirium
    • Headache
    • Elevated LFTs
    • Neutropaenia

Potential Indications
BETA

Migraine

Associated Adverse Effects
BETA

Secondary Hypertension
Secondary Hypertension
Gut
Delirium
Delirium
Acute Kidney Injury
Acute Kidney Injury
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