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Ketoconazole

 
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  •  
    Topical
    Ketoconazole
    Nizoral 

  • Mechanism of Action

  • Inhibits fungal synthesis of ergosterol, and element of the fungal cell membrane.

  • Microbiology

  • Effective against Cryptococcus and Candida.

Clinical Use

  • Indications
  • Topical - tinea corporis, tinea cruris, tinea manus, tinea pedis
  • Systemic – cryptococcal meningitis, candidiasis
  • Adverse Effects
  • With systemic use only:
  • Rash
  • Nausea / vomiting / diarrhoea
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