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Ketamine

  •  
    IV
    Ketamine
    Ketalar 
    • Mechanism of Action
    • Acts as a non-competitive antaagonist at the NMDA receptor
      Reduces presynaptic release of glutamate
      Agonises α and β adrenoceptors
      Agonises opioid σ receptors

Clinical Use

    • Indications
    • Analgesia
    • General anaesthesia for procedures not requiring muscle relaxant
    • Induction of anaesthesia in conjunction with other agents
    • Contraindications
    • Severe cardiovascular disease – heart failure, poorly controlled hypertension, recent MI
    • Past stroke / brain tumour / intracerebral haemorrhage
    • Adverse Effects
    • Tachycardia
    • Hypertension
    • Diplopia / nystagmus
    • Raised intracranial pressure
    • Nausea / vomiting / anorexia

Associated Adverse Effects
BETA

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