Oral
Isosorbide Mononitrate (ISMN)
Imdur, Duride
Long-acting, to be used to control stable angina pectoris
- Mechanism of Action
- Converted to nitrous oxide which stimulates vascular smooth muscle relaxation through stimulation of cGMP-dependant protein kinase with resultant reduction in intracellular calcium.
- Results in venous dilatation (reduced preload), arterial dilatation (reduced afterload) and coronary dilatation (improved myocardial oxygen supply)
Clinical Use
Indications
- Stable angina pectoris
- Adverse Effects
- Flushing
- Headache / dizziness
- Nausea / vomiting
- Postural hypotension / tachycardia / syncope
Want more info like this?
- Your electronic clinical medicine handbook
- Guides to help pass your exams
- Tools every medical student needs
- Quick diagrams to have the answers, fast
- Quizzes to test your knowledge
Sign Up Now