Drug Guide
 

Isosorbide Mononitrate (ISMN)

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    Oral
    Isosorbide Mononitrate (ISMN)
    Imdur, Duride 
     
    Long-acting, to be used to control stable angina pectoris
    • Mechanism of Action
    • Converted to nitrous oxide which stimulates vascular smooth muscle relaxation through stimulation of cGMP-dependant protein kinase with resultant reduction in intracellular calcium.
      Results in venous dilatation (reduced preload), arterial dilatation (reduced afterload) and coronary dilatation (improved myocardial oxygen supply)
    • Pharmacology
    • Long-acting

Clinical Use

    • Indication
    • Stable angina pectoris
    • Adverse Effects
    • Flushing
    • Headache / dizziness
    • Nausea / vomiting
    • Postural hypotension / tachycardia / syncope
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