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Drug Guide
 
 

Isosorbide Mononitrate (ISMN)

 
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    Oral
    Isosorbide Mononitrate (ISMN)
    Imdur, Duride 
     
    Long-acting, to be used to control stable angina pectoris
  • Mechanism of Action
  • Converted to nitrous oxide which stimulates vascular smooth muscle relaxation through stimulation of cGMP-dependant protein kinase with resultant reduction in intracellular calcium.
  • Results in venous dilatation (reduced preload), arterial dilatation (reduced afterload) and coronary dilatation (improved myocardial oxygen supply)
  • Pharmacology

  • Long-acting

Clinical Use

  • Indications

  • Stable angina pectoris
  • Adverse Effects
  • Flushing
  • Headache / dizziness
  • Nausea / vomiting
  • Postural hypotension / tachycardia / syncope
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