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Isosorbide Dinitrate

 
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  •  
    Oral / sublingual
    Isosorbide Dinitrate
    Isordil 
  • Mechanism of Action
  • Converted to nitrous oxide which stimulates vascular smooth muscle relaxation through stimulation of cGMP-dependant protein kinase with resultant reduction in intracellular calcium.
  • Results in venous dilatation (reduced preload), arterial dilatation (reduced afterload) and coronary dilatation (improved myocardial oxygen supply)

Clinical Use

  • Indications
  • Stable angina pectoris
  • Heart failure – especially in the setting of hypertension or MI
  • Adverse Effects
  • Flushing
  • Headache / dizziness
  • Nausea / vomiting
  • Postural hypotension / tachycardia / syncope
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