Drug Guide

Isosorbide Dinitrate

    Oral / sublingual
    Isosorbide Dinitrate
    • Mechanism of Action
    • Converted to nitrous oxide which stimulates vascular smooth muscle relaxation through stimulation of cGMP-dependant protein kinase with resultant reduction in intracellular calcium.
      Results in venous dilatation (reduced preload), arterial dilatation (reduced afterload) and coronary dilatation (improved myocardial oxygen supply)

Clinical Use

    • Indications
    • Stable angina pectoris
    • Heart failure – especially in the setting of hypertension or MI
    • Adverse Effects
    • Flushing
    • Headache / dizziness
    • Nausea / vomiting
    • Postural hypotension / tachycardia / syncope
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