- Oral / sublingualIsosorbide DinitrateIsordil
- Mechanism of Action
- Converted to nitrous oxide which stimulates vascular smooth muscle relaxation through stimulation of cGMP-dependant protein kinase with resultant reduction in intracellular calcium.
Results in venous dilatation (reduced preload), arterial dilatation (reduced afterload) and coronary dilatation (improved myocardial oxygen supply)
- Adverse Effects