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Isoflurane

  •  
    Inhaled
    Isoflurane
    Pungent, rarely used for induction
    • Mechanism of Action
    • Not clearly defined. Alters the configuration of cell membrane ion channels, reducing the rate of firing of action potentials and resulting in CNS depression.

Clinical Use

    • Indication
    • Induction and maintenance of general anaesthesia.
    • Contraindications
    • Past unexplained jaundice or malignant hyperthermia following halothane administration
    • Raised intracranial pressure
    • Adverse Effects
    • Hypotension
    • Bradycardia (halothane / sevoflurane)
    • Tachycardia (desflurane / isoflurane)
    • Cardiac arrhythmia
    • Reduced tidal volume with increased respiratory rate
    • Reduced renal blood flow and glomerular filtration rate
    • Hepatotoxicity
    • Malignant hyperthermia
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